Circulating magnesium and cardiovascular events

نویسندگان

  • Sushmita Das Girish Kumar Singh
  • Pradeep Das
چکیده

In their systematic review and meta-analysis of prospective studies, Del Gobbo et al (1) showed an inverse association of magnesium concentrations with the incidence of cardiovascular disease, including fatal and nonfatal ischemic heart disease (IHD). Yet, another recent meta-analysis (2) has reported a beneficial effect of dietary magnesium on cardiovascular disease mortality among women but not among men. However, the meta-analysis by Del Gobbo et al (1) went one step further by analyzing circulating magnesium, which may suggest the key mechanism of the whole issue. All of the studies included in the meta-analysis by Del Gobbo et al (1) that investigated magnesium in women, either by dietary intake or by circulating concentrations, showed a significant protective effect against IHD incidents (3–5). Among studies that reported strictly on circulating magnesium in women, Chiuve et al (4) showed an inverse association with sudden cardiac death, whereas Liao et al (3) reported a trend toward the decreased risk of IHD. Circulating magnesium is directly regulated by renal function (6). On the contrary, dietary magnesium is mostly associated with individual nutrition and dietary habits. Importantly, there is a low correlation between dietary intake and circulating magnesium concentrations. There are reasons why we should distinguish between circulating magnesium concentrations and dietary magnesium and also separate men from women. Prolonged corrected QT (QTc) interval is associated with an increased risk of potentially fatal ventricular tachyarrhythmias (7–13). Intravenous magnesium has been used for treatment and prevention of ventricular tachycardia (8, 11), ventricular fibrillation (10, 13), and polymorphic ventricular tachycardia (7, 12). Because QTc prolongation is more often present in women, we suggested that the beneficial effect of magnesium could be more pronounced in female patients (14). Pathophysiologic mechanisms may include antagonism at the Land T-type calcium channels (15), membrane stabilization (16), reduced frequency of ventricular ectopic beats (17, 18), and conversion to sinus rhythm (7, 8, 10, 19, 20). Accordingly, there is a compelling evidence of benefit from intravenous magnesium application, and so the effect of the circulating magnesium concentration could be substantial for its cardiovascular effects. The facts that intravenous magnesium is effective against ventricular tachyarrhythmias through mechanisms which include prolongation of the QT interval, and that QTc interval is more often prolonged in women could underlie a better antiarrhythmic protection in women than in men. Perhaps Del Gobbo et al could separate the effect of circulating magnesium in men and women and provide the pooled results. The problem of a low correlation between dietary and circulating magnesium must be accounted for in future research. Neither of the authors declared a conflict of interest.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Circulating magnesium and cardiovascular events.

In their systematic review and meta-analysis of prospective studies, Del Gobbo et al (1) showed an inverse association of magnesium concentrations with the incidence of cardiovascular disease, including fatal and nonfatal ischemic heart disease (IHD). Yet, another recent meta-analysis (2) has reported a beneficial effect of dietary magnesium on cardiovascular disease mortality among women but n...

متن کامل

Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies.

BACKGROUND Clinical hypomagnesemia and experimental restriction of dietary magnesium increase cardiac arrhythmias. However, whether or not circulating or dietary magnesium at usual concentrations or intakes influences the risk of cardiovascular disease (CVD), including fatal ischemic heart disease (IHD), is unclear. OBJECTIVE We performed a systematic review and meta-analysis to investigate p...

متن کامل

Dietary Magnesium and Cardiovascular Disease: A Review with Emphasis in Epidemiological Studies

Magnesium (Mg) is an essential dietary element for humans involved in key biological processes. A growing body of evidence from epidemiological studies, randomized controlled trials (RCTs) and meta-analyses have indicated inverse associations between Mg intake and cardiovascular diseases (CVD). The present review aims to summarize recent scientific evidence on the topic, with a focus on data fr...

متن کامل

Magnesium deficit ? overlooked cause of low vitamin D status?

Like vitamin D deficit, magnesium deficit is considered to be a risk factor for cardiovascular disease. Several steps in the vitamin D metabolism, such as vitamin D binding to its transport protein and the conversion of vitamin D into the hormonal form 1,25-dihydroxyvitamin D by hepatic and renal hydroxylation, depend on magnesium as a cofactor. A new analysis of two National Health and Nutriti...

متن کامل

Magnesium and the Risk of Cardiovascular Events: A Meta-Analysis of Prospective Cohort Studies

BACKGROUND Prospective studies that have examined the association between dietary magnesium intake and serum magnesium concentrations and the risk of cardiovascular disease (CVD) events have reported conflicting findings. We undertook a meta-analysis to evaluate the association between dietary magnesium intake and serum magnesium concentrations and the risk of total CVD events. METHODOLOGY/PR...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014